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French authorities on Thursday announced findings that epilepsy medication valproate is responsible for "severe malformations" in 2,150 to 4,100 children in France.
Women taking the drug during pregnancy are four times more likely to bear children with congenital malformations, according to the report issued jointly by the French National Agency for the Safety of Medicines (ANSM) and the national health insurance administration.

Mahmoud Zureik, ANSM's scientific director and co-author of the report, said the figure of "severe malformations" is notably high in an interview with AFP news agency.

"The study confirms the highly teratogenic nature of valproate," Zureik said, using a medical term for an agent that affects the fetus and produces birth defects.

Authorities said valproate was linked to birth defects that included spina bifida, a condition in which the spinal cord forms in an irregular manner, heart defects and abnormal formation of genital organs.

Although valproate is sold in France under the brand name Depakine (pictured above) by pharmaceutical manufacturer Sanofi, it can also be found in generic forms. Parents of those affected say that public officials were too slow to warn of the drug's side effects, given concerns over its potential effects on fetuses since the 1980s.

Class action lawsuit

Last year, an association of French citizens launched a class action lawsuit against Sanofi for failing to properly inform users of the potential risks associated with the drug.

Marine Martin, who represents the roughly 2,900 families in the lawsuit, told AP news agency in December that the legal process "would be recognition that they (the families) suffered harm."

"We want Sanofi to be condemned because it will be very important for the victims' families," Martin added.

Despite the risks associated with valproate, a 2015 ruling said the drug could still be prescribed to pregnant women after all other forms of epilepsy treatment had been exhausted. ANSM is expected to release a study on the neurological effects of valproate later this year.
New Delhi: Being born with a skin condition can make life difficult for a child and in our society the stigma associated with such physical conditions can make the experience even more devastating. Not long ago a child was labelled as an incarnation of lord hanuman and an alien for a physical condition.

Such is the case of Shama in New Delhi who suffers from a skin condition called lamellar ichthyosis that affects one in six lakh people. The condition has caused hardening of her skin and given her lizard like scale. Her skin also peels off from time to time and leaver her in pain.

The symptoms include plate like scales that are brownish in colour and are caused by genetic issues that affect shedding of skin. It can also lead to over heating and skin tightening as it restricts blood flow.It also leads to difficulty in moving hand joints, hair loss and issues with eyes. Skin cells are produced at normal rates but not shedding normally results in this condition.
Mumbai: India has witnessed a sudden rise in caesarean sections or caesarean deliveries by 15 percent, gynaecologists said on Saturday.

Caesarean deliveries is a procedure performed only during complicated pregnancies and difficulty in a normal vaginal delivery.

Doctors have said that the sudden rise in C-section cases, both in urban and rural areas, are due to delayed marriage and the consequent late child birth, coupled with lifestyle and environmental factors.

Medical science says that if there are no complications with pregnancy or labour, a vaginal birth is safer than a caesarean birth. Vaginal birth also makes future pregnancies and fertility safer.

According to the World Health Organisation (WHO), until 2010, caesarean sections were limited to 8.5 per cent of all deliveries in India. It said, "But in the last decade or so, the numbers have escalated in many parts of the country, reaching as high as 41 per cent of deliveries in Kerala and 58 per cent in Tamil Nadu".

Bandita Sinha, gynaecologist and fertility specialist at World of Women, a leading medical centre for gynaecology cases said, "The alarming factor is that the recommended level of caesarean deliveries by WHO is 10-15 per cent. The sudden increase in the number of caesarean sections is visible in both urban and rural areas."

The lifestyle factors leads to an increasing number of women opting for their first child post 30 years of age.

According to Sinha, there are various indications of a caesarean delivery, like contracted pelvis, where if the size of the baby is not proportionate to the size of the birth canal, normal delivery becomes difficult.

Sinha said, "Health of the scar of any previous uterine surgery also determines if the women will have a natural delivery. Foetal distress or prolonged labour, severe hypertension and other medical conditions can affect mother or baby's health".

Gauri Gore, gynaecologist at city-based Zen Hospital, said: "Sometimes, the caesarean-section becomes risky if the mother has genital herpes. So, it has to be ensured that the mother's infection does not pass on to the baby."

Gore said that a sedentary lifestyle or lack of exercise could also increase the possibility of a C-section.
New York: While the maternal mortality rates are declining worldwide, the situation for women in the United States is a glaring exception.

And in Texas, where clinics serving women have shuttered and their health interests have been battled all the way up to the US Supreme Court, the rate of pregnancy-related deaths more than doubled over the course of two years.

These are some of the findings in a new study (PDF) in the September issue of Obstetrics & Gynecology.The authors set out to analyze maternal mortality trends in part because the United States government has not published official data on this subject since 2007, they said, calling that fact an "international embarrassment."

One of the eight United Nations Millennium Development Goals sought a 75% reduction in pregnancy-related deaths from 1990 to 2015. Just as the world turned its attention to this matter with marked success, the United States stopped offering data and began moving backward.

Funding challenges and a tangled mess of inconsistent measurements may have been to blame for the lack of information, the authors said.

The United States performs worse than any other developed nation when it comes to maternal death, according to State of the World's Mothers 2015, the most recent comprehensive report compiled by Save the Children, a 90-year old global organization advocating for kids' needs.

In the United States, a woman faces a one in 1,800 chance of dying from a pregnancy-related cause during her reproductive years, that report says. She's 10 times more likely to die this way than a woman living in Poland, Austria or Belarus.

Pregnancy-related deaths are still rare in the United States, certainly in comparison with less-developed nations. But the estimated rate of maternal mortality in 48 states and Washington grew by about 27% between 2000 and 2014, said the authors of the newer study.

The two most populous states, California and Texas, had enough data to allow for more analysis. Research showed that California succeeded in decreasing numbers, the researchers said, but Texas death rates climbed like no other state in the nation.
The trouble with Texas

From 2006 through 2010, numbers from the National Center for Health Statistics show that the rate of maternal deaths in Texas wavered little. There were as few as 69 deaths in 2009 and as many as 82 in 2008.

But from 2010 to 2012, those numbers shot up from 72 deaths to 148. In 2013, deaths fell slightly to 140, and there were 135 in 2014, the last year analyzed by the study's researchers.

Advocates for reproductive rights -- including the right to legal and safe abortions -- were quick to seize upon the news with their analysis about the trend in Texas.

The uptick is no coincidence, they say. In this same window of time, Texas politicians voted to defund Planned Parenthood and slashed family planning dollars, reducing access to more than abortions.

Other services provided by Planned Parenthood, which often caters to underserved communities, include breast and cervical cancer screenings, contraceptive counseling, STD testing and treatment, and multiple forms of preventive women's care.

"For many of our patients, Planned Parenthood and other family planning clinics are their gateway to the health care system," said Sarah Wheat, chief external affairs officer for Planned Parenthood of Greater Texas, in a written statement.

"Women have been left out in the cold, without being able to obtain regular healthcare screenings, or birth control to space their pregnancies, and delays in their initial pregnancy test and prenatal referral -- all of which are harmful to women's health."

She and other activists say these developments are among a string of examples of Texas leadership putting politics above all else.

The passage of Texas' House Bill 2 in 2013 placed so many restrictions on abortion clinics that half of them closed, creating an abortion desert for those seeking the procedure. That law was struck down by the nation's highest court in late June.

Soon after, though, came a rule that will require the burial or cremation of all fetal remains in Texas -- adding a new emotional and financial burden for women, including those who miscarry.

And this month, Texas announced plans to distribute $18 million in the form of 31 grants to support low-income women's health care, including gynecological exams, birth control and cancer screenings.

The second-highest award of $1.6 million went to the Heidi Group, which critics claim is an anti-abortion group with no experience offering medical services.

"It's time to stop these political attacks before even more women pay the price with their health and lives," Wheat said.
Identifying the cause

Pegging the spike of Texas maternal deaths in 2011-12 on politics and the closure of clinics isn't fair, said Carrie Williams, a spokeswoman for the Texas Department of State Health Services.

"There is no evidence of that," she said by email. "That reduction [in clinics] wouldn't have taken effect till September 2011 and it would have taken months to be reflected in the type of data we are talking about here.
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She said that the concern about the uptick in deaths is one the department shares and that it's "a complex problem that requires looking closely at a number of factors," including obesity, chronic disease and tobacco use. For that reason, she said, a task force has been set up to examine what transpired and offer recommendations.

Marian MacDorman, the lead author of the recent study that highlighted the Texas numbers, said the goal in the research was simply to identify trends and not answer why Texas numbers jumped.

Even so, the maternal and child health research professor at University of Maryland gives weight to the idea that the closure of women's health clinics in recent years played a role.

"It's certainly a theory," she said. "And I don't have a lot of other theories at the moment."
Bigger than one state

The Texas numbers may be the most striking. But the maternal mortality trend is a national problem, the new study's authors make clear. And this point is driven home by the analysis of others.

Of 183 countries and territories studied from 1990 to 2013, only 17 saw maternal mortality rate percentage increases, the World Health Organization report "Trends in Maternal Mortality: 1990 to 2013" showed. In the United States, the maternal mortality rate grew by 136% over those 23 years, more than any other country studied.

All of this echoes what the authors of the new US study mean when they say it's time to "redouble efforts to prevent maternal deaths and improve maternity care for the 4 million U.S. women giving birth each year."
Girls who start menstruating at a younger age are 50% more likely to develop gestational diabetes, researchers including one of Indian origin have found.

Gestational diabetes is an increasingly common pregnancy complication and can have long-lasting health consequences for mothers and their children.

Researchers from University of Queensland in Australia analysed data from more than 4,700 women and found a higher number of women who reported having their first period at a younger age had later developed gestational diabetes.Those who had their first period at age 11 or younger were 50% more likely to develop gestational diabetes than those who experienced their first period at age 13, said Danielle Schoenaker.

“This finding could mean that health professionals will start asking women when they had their first period to identify those at higher risk of gestational diabetes,” Schoenaker added.


Early puberty in girls has now been shown to be a significant marker for several adverse health outcomes, including gestational diabetes, said Professor Gita Mishra, Director of Australian Longitudinal Study on Women’s Health.A large proportion of women who develop diabetes during pregnancy are overweight or obese and encouraging those with an early start of puberty to control their weight before pregnancy may help to lower their risk of gestational diabetes,” said Schoenaker.
A recent study estimates that around 200 million cases of diseases of polio, mumps, rubella, measles, adenovirus, hepatitis A and rabies have been prevented in the U.S. with the help of vaccination from 1963 to 2015.

The study also reveals that about 450,000 deaths have been avoided in the U.S during this period.

The vaccination became widespread in 1963 after the safe production of these vaccines started due to the discovery of the human cell strain. The vaccines produced from these cell strains prevented almost 4.5 billion occurrences of the diseases and also stopped them from coming back in over 10 million people worldwide in 1963.
The Human Cell Strain

In 1962, Leonard Hayflick, co-author of the study, discovered the regular human cell strain. This cell strain enabled the growth of viruses, which are in turn required to manufacture vaccines. Scientists were able to develop vaccines for 10 diseases using the human cell strain.

However, the production of vaccines came to an end leaving millions of people unprotected against several diseases. The vaccines saw an end due to the viral vaccines of monkey cells.

"Given the acknowledged large, positive global health impact of vaccines in general, I was curious what contribution my discovery of WI-38 in 1962 had in saving lives and reducing morbidity, since a large number of viral vaccines in use today are made with my cell strain or its derivatives," said Hayflick.
The Study

Hayflick collaborated with S. Jay Olshansky and conducted the study to discover the sheer number of deaths and diseases prevented by WI-38 till 2015. Olshansky checked with earlier data pertaining to the cases and deaths for each disease that occurred in the U.S. in 1960.

It was the year when vaccines were not available for prevention of the diseases. He made an assumption that the death and disease occurrence rates were constant throughout the year.

To study the number of reports where lives have been saved and the disease prevented, Olshansky multiplied the number of years vaccines have been prevalent by the number of deaths due to the disease.
Findings Of The Study

The study showed that the parents in California feared the use of vaccines. As a result, unvaccinated children suffered from acute measles, causing an outbreak in 2014 and 2015. Olshansky noted that the unvaccinated children did not only pose problems for themselves, but also lowered the herd immunity.

The study estimated that around 1.4 million unvaccinated children under 5 years die each year. Moreover, the researcher noted that anti-vaccine movement in the U.S. is creating a negative environment in the country, due to which vaccination rates for several diseases are as little as 50 percent to 86 percent.

Vaccines offer several life-saving and primary prevention benefits. Additionally, Hayflick asserted that there isn't any medication or public health innovation that can replace the vaccines.
Horse-riding is not among the most common forms of physical activity in the country, and probably that's why only few possess the skills of riding a horse and enjoying it. Having said that, most metro cities have horse riding facilities that you could sign up for and learn the sport, but it doesn't always top one's priority list. If you have grown up watching Western movies then somewhere deep down you may have felt that itch to be able to ride a horse like a pro, galloping over wide fields or along the sea. May be it's time to live that dream, if not for you, then at least for your little kid.

According to a new study by Tokyo University in Japan, horse riding may help improve mental skills in kids. Mental or cognitive skills are very important for a kid's growth and development to help him become a successful individual in the future. Cognitive skills include enhanced learning, memory and problem-solving abilities, among others.
The study showed that the effects of vibrations produced by horses during horse riding leads to the activation of the sympathetic nervous system, which may improve learning in children. Horse steps produce three-dimensional accelerations and the movement of the horse's pelvis may provide motor and sensory inputs to the human body.

"Some of the differences among the rider's performances might be due to these accelerations," said Mitsuaki Ohta, lead author of the study.

"We wanted to look into these effects because previous studies have demonstrated the benefits of horseback riding with respect to enhancing physical health and the mental effects, but few studies have addressed the effects of horseback riding on children and the mechanisms underlying how riding affects humans," explained Ohta.

The findings, published in the journal Frontiers in Public Health, showed that riding on some horses greatly improved the ability of children to perform behavioural tasks and improve cognitive abilities. These are brain-based skills of which an improvement can lead to enhanced learning, memory and problem-solving, the researchers said.

For the study, the team examined the effects of horseback riding on the performance of children by having them complete simple tests directly before and after horse riding, while measuring the children's heart rate in response to movements created by the horses. The behavioural reactions of the children were tested using a 'Go/No-go' test, which assesses cognitive response using fast computerised questions.

The test determined the children's ability to appropriately respond in a situation, by either performing an action or demonstrating self-control.

Inputs from IANS
"Some of the differences among the rider's performances might be due to these accelerations," said Mitsuaki Ohta, lead author of the study.

"We wanted to look into these effects because previous studies have demonstrated the benefits of horseback riding with respect to enhancing physical health and the mental effects, but few studies have addressed the effects of horseback riding on children and the mechanisms underlying how riding affects humans," explained Ohta.


The findings, published in the journal Frontiers in Public Health, showed that riding on some horses greatly improved the ability of children to perform behavioural tasks and improve cognitive abilities. These are brain-based skills of which an improvement can lead to enhanced learning, memory and problem-solving, the researchers said.

For the study, the team examined the effects of horseback riding on the performance of children by having them complete simple tests directly before and after horse riding, while measuring the children's heart rate in response to movements created by the horses. The behavioural reactions of the children were tested using a 'Go/No-go' test, which assesses cognitive response using fast computerised questions.


The test determined the children's ability to appropriately respond in a situation, by either performing an action or demonstrating self-control.


Inputs from IANS